Endocrine Abstracts

Background: Chronic hypoparathyroidism is a relatively rare disease associated with various complications. The analysis of large databases of patients with chronic hypoparathyroidism is a necessary tool to enhance quality of medical care, as well as to determine the therapeutic approaches and prognostic markers of the disease.Aims: To describe complications associated with chronic hypoparathyroidism and determine predictors of their development according...

Background: Parathyroid cancer (P?) in children is extremely rare, more often sporadic, but may be associated with a germline mutation. The only effective treatment is surgical approach due to the chemo-radio-resistance of PC.Clinical case: A 6-years-old girl presented with weakness, gait disturbance, pain in the limbs, an X-shaped curvature of the legs. At the age of 12, the patient’s well-being worsened sharply. The laboratory examination revealed...

Objective: Primary hyperparathyroidism (PHPT) is associated with increased cardiovascular morbidity including hypertension with a prevalence ranging from 40 to 65%. The renin-angiotensin-aldosterone system (RAAS) is a key system in the regulation of sodium/potassium balance, volume homeostasis as well as blood pressure. There is increasing evidence of interactions between calcium and calcium-regulatory hormones with the RAAS. The aim of this study was to investigate the associ...

Background: DiGeorge syndrome (DGS) is the rare genetic disorder caused by a 22q11.2 chromosome microdeletion. The main clinical features are associated with defective development of the pharyngeal pouch system and usually include congenital heart disease, hypoplasia of thymus resulting in immune deficiency and hypoparathyroidism. Also DGS patient has characteristic long face with narrow palpebral fissures, broad nasal bridge, micrognathia and small mouth, small dysmorphic ear...

Background: Approximately 25% of patients with parathyroid carcinoma (PC) have metastases; the most frequent sites include cervical lymph nodes (30%) and lungs (40%). Less common are liver, bones and brain. Surgical resection of local or distant metastases (if possible) provides the best control of hypercalcemia and enhances long-term survival.Case description: A 70-year old patient was admitted to hospital with a primary hyperparathyroidism (PH). He did...

Introduction: Atypical parathyroid adenoma (APA) is rarely encountered cause of primary hyperparathyroidism (PHPT). No definite criteria are considered to distinguish preoperatively APA from parathyroid typical adenoma or carcinoma.The aimTo describe the clinical course of a patient with an atypical parathyroid adenoma with severe hypercalcemia and multiple fragility fractures.Case presentation: A 61-year-old...

Background: In most cases of parathyroid carcinoma (PC) only recurrence could be a credible feature of malignancy.Clinical case: At the age of 19 years a woman was diagnosed with urolithiasis. At the age of 22 years she had a surgical resection of the neck nodule at the right site in the projection of carotid triangle. After the histological study, ectopic parathyroid tumor was misdiagnosis with paraganglioma (material is available for review). At the ag...

Factors affecting the development of nephrolithiasis (NL) in primary hyperparathyroidism (PHPT) actively studied. CASR polymorphisms may be linked with the development of NL in PHPT. Supposed to the role of VDR in the development of nephrolithiasis in patients without PHPT.Objective: To assess the relationship of polymorphisms CASR and VDR with the development of the NL at PGPT.Methods: The study included 187 patients with PTPT (54...

Clinical manifestations and severity vary considerably primary hyperparathyroidism (PHPT) patients. Several studies indicate that the variation of clinical manifestations PHPT may be associated with genetic factors, in particular the VDR gene polymorphisms and CASR. The purpose of this study was to evaluate the effect of VDR gene polymorphisms and CASR on indicators calcium and phosphorus metabolism, levels of 25(OH)D, PTH, and condition of bone density in patients with PHPT.<...

Much attention is attracted increased risk of fractures in patients with urolithiasis. Study the possible relationship of pathophysiological mechanisms of osteoporosis/osteopenia and nephrolithiasis.Objective: To assess the state of bone metabolism, vitamin D level in patients with urolithiasis compared with healthy individuals.Methods: Were examined 58 patients with nephrolithiasis (36 women, and 22 men) and 20 healthy individuals...